Those two gigantic PSMA review papers in European Urology - Perera et al 2016 and Perera et al 2020 - have been cited more than 2000 times and have been the definitive reference for anyone writing about PSMA PET/CT in the past ten years. And they have just been updated in two new papers just published in European Urology! Previous first author (Marlon) Perera, has moved to senior author, while Elio Mazzone has led both papers as first author, co-ordinating a massive effort between research teams in Melbourne and Milano. One paper is focused on diagnosis and staging, and the other on assessment of recurrence.

A beachside interview with Michael Hofman to hear all the PSMA theranostic highlights at ASCO this year! Yes we left our suburban studio in Melbourne and wandered down to St Kilda beach to track down Michael for a beer and a chat. Even in mid-Winter we enjoyed sitting out in a beachside shack at the Beachcomber Cafe and Beach Bar.

What is Histolog?? Well, now that intra operative margin assessment is a such a hot topic in prostate cancer surgery after the Neurosafe RCT read-out, we thought we would dive into one of the other new technologies for doing something similar, but without the pragmatic challenges of frozen section. The idea is to assess the surgical margin of the prostate at the time of surgery to improve nerve sparing and sexual function for patients.

A wonderful meandering chat with Ketan Badani (Urologist, Mt Sinai, NYC)! We took him for a wine tour in the Yarra Valley, stopping for a pod chat at Rochford Winery about screening for prostate cancer in older men, plus a great tour around Healesviile Sanctuary to introduce Ketan to some Australian wildlife. Then back in Melbourne we had another chat, this time a bit of future-gazing about the future of surgery, and Declan and Ketan trade tales about EMR (that's Electronic Medical Record) delinquency.

A Masterclass in advanced kidney cancer today with the great Danny Heng (University of Calgary, Canada), and our own Lewis Au (Peter MacCallum Cancer Centre, Melbourne)! Both popped into the GU Cast studio while Danny was in Australia doing some lectures and visiting us at Peter Mac. We challenged Danny and Lewis to simplify three hot topics in kidney cancer, ideal if (like us) you find it difficult to keep up with this fast-moving area. The three areas are: 1. What sort of patient is this? Risk stratification made easy (by Danny, Master of the universe of Risk Stratification in kidney cancer) 2. Novel scans and biomarkers in kidney cancer - a bluffers guide 3. Neoadjuvant and adjuvant therapies in kidney cancer - what the urologist needs to know

Meet the young new faces of collaborative urological research!! GU Cast host Declan Murphy discusses the latest in international collaborative trials with A/Prof Veeru Kasivisvanathan, Dr Alexander Ng, and highly ambitious medical students, Miss Aishwarya Shah and Mr Alexander Dudko. They discuss their latest research from the COMPASS group including the PRIME trial (bpMRI vs mpMRI in detecting prostate cancer), and upcoming PARADIGM (AI vs Radiologists in detecting prostate cancer trials. And from BURST Urology we hear an update from the RESECT (can audit and feedback improve TURBT outcomes?) trial.

When Fred Saad (Urologist, University of Montreal, Montreal) and Andrew Weickhardt (Medical Oncologist, Austin Health, Melbourne) popped into our studio recently we decided to pick their brains on a few hot topics in mHSPC - we called it the ABC of mHSPC! Fred was in Melbourne to visit Peter Mac and do some educational talks and we loved welcoming him back on GU Cast.

A big welcome back to EAU Guideline gurus, Dr Derya Tilki (Martini-Klinik, Hamburg, Germany), and Dr Gianluca Giannarini (Santa Maria della Misericordia University Hospital, Udine, Italy), for an overview of the major headlines from this year's EAU Guideline update. Derya is Deputy Chair of the EAU Prostate Cancer Guideline Committee and has picked out four areas to discuss.

For serious PSMA theranostics enthusiasts!!! We bring you the ninth of our collaborative PSMA webinars over the past five years, in collaboration with our team at ProsTIC and at the Prostate Cancer Foundation in the US. A truly outstanding faculty presenting today including Misha Beltran, Marty Pomper, Ed Kwan and Louise Emmett.

What is the da Vinci Single Port (SP) robot and is it any good? Is it easy to transition from the multiport robot to a single port robot? What about Retzius-sparing prostatectomy using the SP robot? GU Cast hosts Declan Murphy and Renu Eapen learn the answers to these questions and more when we visit top prostate cancer surgeons Dr Declan Cahill and Prof Chris Eden at London Bridge Hospital, to see the UK's only SP robot in action. The SP robot has been approved in the US for a few years, and now approved in Europe and Australia, so we hope to have it available for our patients very soon. Plus we see how they use the Neurosafe intra-operative margin assessment technique at London Bridge Hospital.

Like very many countries around the world our friends in China are big fans of the EAU Guidelines, and are always tuned in when the updated Prostate Cancer Guidelines is released every year. So as part of our China Themed Episode Series, supported by our Gold Partners Bayer China, we are discussing some key updates to this year's Guideline with our China Editor Dr Yao Zhu (Shanghai) along with Dr Junlong Zhuang (Nanjing).

bit of a break from the usual GU Oncology routine today folks! Declan was back at Guy's Hospital recently doing a talk and heard a remarkable story told by one of the Urology Fellows, Dr Joachim Jimie. A quite spectacular mid-air crisis, and some great life lessons in there also. Declan could not resist the opportunity to grab Jimie and tell the tale again for GU Cast. Enjoy!!!

Radiation cystitis! Now this can be a really challenging condition for urologists, and especially for patients, to manage and to live with. And we frequently struggle to get good results. It is often years and years after radiation to the pelvis when patients return with problems like bleeding, pain, incontinence, fistula etc, which can have everything from minor, to ruinous effects on quality of life. Today we travel to London to chat with two Urologists at Guy’s Hospital who have set up a dedicated clinic to manage Radiation Cystitis patients from across the UK

More great highlights from the recent EAU Annual Meeting in Madrid. Declan and Renu chat with Christian Gratzke, Sima Pore]ten, Yinjie Zhu, Rod Dunn, and have a most entertaining "pit lane walk" with Ben Challacombe around the various robots in the exhibition area

Declan and Renu bring you some great highlights from the recent EAU Annual Meeting in Madrid. Hear from Laurie Klotz and Adam Kinnaird about the OPTIMUM RCT, Sarah Psutka and Laura Bukavina discuss their bladder cancer highlights, Riccardo Campi talks biomarkers, changes in practice and other highlights, and Rod van den Bergh and Eoin Dinneen debate the finer points of the NEUROSAFE Proof RCT.

Really big prostate cancer news today with the release of very interesting results from the Neurosafe Proof trial at the EAU Annual Meeting in Madrid. Also simultaneously published in Lancet Oncology so this is a big deal!! In summary, this multi centre randomised trial from the UK demonstrates that men undergoing the Neurosafe technique (intra-operative assessment of surgical margins), had higher rates of nerve sparing surgery and this in turn led to improvements of recover of sexual function.

We are delighted to drop this pod just as the landmark TRANSLATE trial reads out at the EAU Annual Meeting in Madrid, with a simultaneous publication in Lancet Oncology. This is the world's largest trial of transrectal vs transperineal (TP) prostate biopsy, and reports that TP biopsy has superior cancer detection ability. Is this the end of the road for TRUS biopsy

This week we had the great pleasure of attending the Annual Scientific Meeting of the Urological Society of Australia and New Zealand (USANZ), which took place in the beautiful city of Perth, far out on the West Coast of Australia. Not just that, but we spent a wonderful afternoon on one of Australia’s top tourist attractions, Rottnest Island. Tune in for plenty of quokka action!

A fantastic deep dive into biochemical recurrence, with Dr Steve Freedland. A must-listen for anyone interested in localised prostate cancer. Supported by our Gold Partners, Astellas.

Two great interviews here, with international guests Kim Chi and Carmen Mir, and a bunch of friends. We discuss mHSPC, and also a fun chat about doing Fellowship training in Australia.